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KMID : 1177720110050010061
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Journal of Alternatives to Animal Experiments
2011 Volume.5 No. 1 p.61 ~ p.64
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In Silico QSAR models for the risk scoring of developmental neurotoxic chemicals originated from Food
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Jung Yeon-Hwa
Kim Young-Won
Min Jeong-Ran
Jeong Sang-Hee
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Abstract
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Developmental neurotoxicity (DNT) of chemicals is a serious threat to human health. Exposure to DNT during the perinatal period can result in behavioral abnormalities and cognitive deficits that appear later in life. The aims of this study were to predict human health impact of chemicals via food ingestion using chemical structure-based toxicity predicting program (In Silico QSAR). The determination factors that affect DNT risk potency were selected as developmental toxicity potential (DTP), blood-brain-barrier transfer, a predictor of logarithm of n-octanol/water partition coefficient (VLOGP),rat oral LD50, and rat chronic oral lowest-observed-adverse effect level (LOAEL). 39 kinds of chemicals were identified as high DNT potential chemicals. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and hexachlorobenzene are classified as high DNT potential chemicals. Those chemicals need to be carefully treated as probable high potent DNTs and full scaled in vivo studies are required to characterize the risk of DNT.
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KEYWORD
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Development Neurotoxicity, Risk Assessment, Food chemical hazards
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